Mutation of FOXL2 in granulosa-cell tumors of the ovary.
Identifieur interne : 001E08 ( Main/Exploration ); précédent : 001E07; suivant : 001E09Mutation of FOXL2 in granulosa-cell tumors of the ovary.
Auteurs : Sohrab P. Shah [Canada] ; Martin Köbel ; Janine Senz ; Ryan D. Morin ; Blaise A. Clarke ; Kimberly C. Wiegand ; Gillian Leung ; Abdalnasser Zayed ; Erika Mehl ; Steve E. Kalloger ; Mark Sun ; Ryan Giuliany ; Erika Yorida ; Steven Jones ; Richard Varhol ; Kenneth D. Swenerton ; Dianne Miller ; Philip B. Clement ; Colleen Crane ; Jason Madore ; Diane Provencher ; Peter Leung ; Anna Defazio ; Jaswinder Khattra ; Gulisa Turashvili ; Yongjun Zhao ; Thomas Zeng ; J N Mark Glover ; Barbara Vanderhyden ; Chengquan Zhao ; Christine A. Parkinson ; Mercedes Jimenez-Linan ; David D L. Bowtell ; Anne-Marie Mes-Masson ; James D. Brenton ; Samuel A. Aparicio ; Niki Boyd ; Martin Hirst ; C Blake Gilks ; Marco Marra ; David G. HuntsmanSource :
- The New England journal of medicine [ 1533-4406 ] ; 2009.
English descriptors
- KwdEn :
- Base Sequence, Female, Forkhead Transcription Factors (genetics), Gene Expression Profiling, Genetic Markers, Genotype, Granulosa Cell Tumor (diagnosis), Granulosa Cell Tumor (genetics), Granulosa Cell Tumor (pathology), Humans, Immunohistochemistry, Mutation, Missense, Ovarian Neoplasms (diagnosis), Ovarian Neoplasms (genetics), Ovarian Neoplasms (pathology), Point Mutation, Sequence Analysis, RNA, Taq Polymerase.
- MESH :
- chemical , genetics : Forkhead Transcription Factors.
- diagnosis : Granulosa Cell Tumor, Ovarian Neoplasms.
- genetics : Granulosa Cell Tumor, Ovarian Neoplasms.
- pathology : Granulosa Cell Tumor, Ovarian Neoplasms.
- Base Sequence, Female, Gene Expression Profiling, Genetic Markers, Genotype, Humans, Immunohistochemistry, Mutation, Missense, Point Mutation, Sequence Analysis, RNA, Taq Polymerase.
Abstract
Granulosa-cell tumors (GCTs) are the most common type of malignant ovarian sex cord-stromal tumor (SCST). The pathogenesis of these tumors is unknown. Moreover, their histopathological diagnosis can be challenging, and there is no curative treatment beyond surgery.
DOI: 10.1056/NEJMoa0902542
PubMed: 19516027
Affiliations:
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Mutation of FOXL2 in granulosa-cell tumors of the ovary.</title>
<author><name sortKey="Shah, Sohrab P" sort="Shah, Sohrab P" uniqKey="Shah S" first="Sohrab P" last="Shah">Sohrab P. Shah</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Translational and Applied Genomics, British Columbia Cancer Agency, Vancouver, Canada.</nlm:affiliation>
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<wicri:noRegion>Vancouver</wicri:noRegion>
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<author><name sortKey="Kobel, Martin" sort="Kobel, Martin" uniqKey="Kobel M" first="Martin" last="Köbel">Martin Köbel</name>
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<author><name sortKey="Senz, Janine" sort="Senz, Janine" uniqKey="Senz J" first="Janine" last="Senz">Janine Senz</name>
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<author><name sortKey="Morin, Ryan D" sort="Morin, Ryan D" uniqKey="Morin R" first="Ryan D" last="Morin">Ryan D. Morin</name>
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<author><name sortKey="Clarke, Blaise A" sort="Clarke, Blaise A" uniqKey="Clarke B" first="Blaise A" last="Clarke">Blaise A. Clarke</name>
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<author><name sortKey="Wiegand, Kimberly C" sort="Wiegand, Kimberly C" uniqKey="Wiegand K" first="Kimberly C" last="Wiegand">Kimberly C. Wiegand</name>
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<author><name sortKey="Leung, Gillian" sort="Leung, Gillian" uniqKey="Leung G" first="Gillian" last="Leung">Gillian Leung</name>
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<author><name sortKey="Kalloger, Steve E" sort="Kalloger, Steve E" uniqKey="Kalloger S" first="Steve E" last="Kalloger">Steve E. Kalloger</name>
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<author><name sortKey="Sun, Mark" sort="Sun, Mark" uniqKey="Sun M" first="Mark" last="Sun">Mark Sun</name>
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<author><name sortKey="Giuliany, Ryan" sort="Giuliany, Ryan" uniqKey="Giuliany R" first="Ryan" last="Giuliany">Ryan Giuliany</name>
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<author><name sortKey="Yorida, Erika" sort="Yorida, Erika" uniqKey="Yorida E" first="Erika" last="Yorida">Erika Yorida</name>
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<author><name sortKey="Jones, Steven" sort="Jones, Steven" uniqKey="Jones S" first="Steven" last="Jones">Steven Jones</name>
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<author><name sortKey="Varhol, Richard" sort="Varhol, Richard" uniqKey="Varhol R" first="Richard" last="Varhol">Richard Varhol</name>
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<author><name sortKey="Swenerton, Kenneth D" sort="Swenerton, Kenneth D" uniqKey="Swenerton K" first="Kenneth D" last="Swenerton">Kenneth D. Swenerton</name>
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<author><name sortKey="Miller, Dianne" sort="Miller, Dianne" uniqKey="Miller D" first="Dianne" last="Miller">Dianne Miller</name>
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<author><name sortKey="Madore, Jason" sort="Madore, Jason" uniqKey="Madore J" first="Jason" last="Madore">Jason Madore</name>
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<author><name sortKey="Provencher, Diane" sort="Provencher, Diane" uniqKey="Provencher D" first="Diane" last="Provencher">Diane Provencher</name>
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<author><name sortKey="Leung, Peter" sort="Leung, Peter" uniqKey="Leung P" first="Peter" last="Leung">Peter Leung</name>
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<author><name sortKey="Defazio, Anna" sort="Defazio, Anna" uniqKey="Defazio A" first="Anna" last="Defazio">Anna Defazio</name>
</author>
<author><name sortKey="Khattra, Jaswinder" sort="Khattra, Jaswinder" uniqKey="Khattra J" first="Jaswinder" last="Khattra">Jaswinder Khattra</name>
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<author><name sortKey="Turashvili, Gulisa" sort="Turashvili, Gulisa" uniqKey="Turashvili G" first="Gulisa" last="Turashvili">Gulisa Turashvili</name>
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<author><name sortKey="Zhao, Yongjun" sort="Zhao, Yongjun" uniqKey="Zhao Y" first="Yongjun" last="Zhao">Yongjun Zhao</name>
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<author><name sortKey="Zeng, Thomas" sort="Zeng, Thomas" uniqKey="Zeng T" first="Thomas" last="Zeng">Thomas Zeng</name>
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<author><name sortKey="Glover, J N Mark" sort="Glover, J N Mark" uniqKey="Glover J" first="J N Mark" last="Glover">J N Mark Glover</name>
</author>
<author><name sortKey="Vanderhyden, Barbara" sort="Vanderhyden, Barbara" uniqKey="Vanderhyden B" first="Barbara" last="Vanderhyden">Barbara Vanderhyden</name>
</author>
<author><name sortKey="Zhao, Chengquan" sort="Zhao, Chengquan" uniqKey="Zhao C" first="Chengquan" last="Zhao">Chengquan Zhao</name>
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<author><name sortKey="Parkinson, Christine A" sort="Parkinson, Christine A" uniqKey="Parkinson C" first="Christine A" last="Parkinson">Christine A. Parkinson</name>
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<author><name sortKey="Jimenez Linan, Mercedes" sort="Jimenez Linan, Mercedes" uniqKey="Jimenez Linan M" first="Mercedes" last="Jimenez-Linan">Mercedes Jimenez-Linan</name>
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<author><name sortKey="Bowtell, David D L" sort="Bowtell, David D L" uniqKey="Bowtell D" first="David D L" last="Bowtell">David D L. Bowtell</name>
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<author><name sortKey="Mes Masson, Anne Marie" sort="Mes Masson, Anne Marie" uniqKey="Mes Masson A" first="Anne-Marie" last="Mes-Masson">Anne-Marie Mes-Masson</name>
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<author><name sortKey="Brenton, James D" sort="Brenton, James D" uniqKey="Brenton J" first="James D" last="Brenton">James D. Brenton</name>
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<author><name sortKey="Aparicio, Samuel A" sort="Aparicio, Samuel A" uniqKey="Aparicio S" first="Samuel A" last="Aparicio">Samuel A. Aparicio</name>
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<author><name sortKey="Boyd, Niki" sort="Boyd, Niki" uniqKey="Boyd N" first="Niki" last="Boyd">Niki Boyd</name>
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<author><name sortKey="Hirst, Martin" sort="Hirst, Martin" uniqKey="Hirst M" first="Martin" last="Hirst">Martin Hirst</name>
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<author><name sortKey="Gilks, C Blake" sort="Gilks, C Blake" uniqKey="Gilks C" first="C Blake" last="Gilks">C Blake Gilks</name>
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<term>Female</term>
<term>Forkhead Transcription Factors (genetics)</term>
<term>Gene Expression Profiling</term>
<term>Genetic Markers</term>
<term>Genotype</term>
<term>Granulosa Cell Tumor (diagnosis)</term>
<term>Granulosa Cell Tumor (genetics)</term>
<term>Granulosa Cell Tumor (pathology)</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Mutation, Missense</term>
<term>Ovarian Neoplasms (diagnosis)</term>
<term>Ovarian Neoplasms (genetics)</term>
<term>Ovarian Neoplasms (pathology)</term>
<term>Point Mutation</term>
<term>Sequence Analysis, RNA</term>
<term>Taq Polymerase</term>
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<term>Ovarian Neoplasms</term>
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<term>Female</term>
<term>Gene Expression Profiling</term>
<term>Genetic Markers</term>
<term>Genotype</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Mutation, Missense</term>
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<front><div type="abstract" xml:lang="en">Granulosa-cell tumors (GCTs) are the most common type of malignant ovarian sex cord-stromal tumor (SCST). The pathogenesis of these tumors is unknown. Moreover, their histopathological diagnosis can be challenging, and there is no curative treatment beyond surgery.</div>
</front>
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<name sortKey="Mehl, Erika" sort="Mehl, Erika" uniqKey="Mehl E" first="Erika" last="Mehl">Erika Mehl</name>
<name sortKey="Mes Masson, Anne Marie" sort="Mes Masson, Anne Marie" uniqKey="Mes Masson A" first="Anne-Marie" last="Mes-Masson">Anne-Marie Mes-Masson</name>
<name sortKey="Miller, Dianne" sort="Miller, Dianne" uniqKey="Miller D" first="Dianne" last="Miller">Dianne Miller</name>
<name sortKey="Morin, Ryan D" sort="Morin, Ryan D" uniqKey="Morin R" first="Ryan D" last="Morin">Ryan D. Morin</name>
<name sortKey="Parkinson, Christine A" sort="Parkinson, Christine A" uniqKey="Parkinson C" first="Christine A" last="Parkinson">Christine A. Parkinson</name>
<name sortKey="Provencher, Diane" sort="Provencher, Diane" uniqKey="Provencher D" first="Diane" last="Provencher">Diane Provencher</name>
<name sortKey="Senz, Janine" sort="Senz, Janine" uniqKey="Senz J" first="Janine" last="Senz">Janine Senz</name>
<name sortKey="Sun, Mark" sort="Sun, Mark" uniqKey="Sun M" first="Mark" last="Sun">Mark Sun</name>
<name sortKey="Swenerton, Kenneth D" sort="Swenerton, Kenneth D" uniqKey="Swenerton K" first="Kenneth D" last="Swenerton">Kenneth D. Swenerton</name>
<name sortKey="Turashvili, Gulisa" sort="Turashvili, Gulisa" uniqKey="Turashvili G" first="Gulisa" last="Turashvili">Gulisa Turashvili</name>
<name sortKey="Vanderhyden, Barbara" sort="Vanderhyden, Barbara" uniqKey="Vanderhyden B" first="Barbara" last="Vanderhyden">Barbara Vanderhyden</name>
<name sortKey="Varhol, Richard" sort="Varhol, Richard" uniqKey="Varhol R" first="Richard" last="Varhol">Richard Varhol</name>
<name sortKey="Wiegand, Kimberly C" sort="Wiegand, Kimberly C" uniqKey="Wiegand K" first="Kimberly C" last="Wiegand">Kimberly C. Wiegand</name>
<name sortKey="Yorida, Erika" sort="Yorida, Erika" uniqKey="Yorida E" first="Erika" last="Yorida">Erika Yorida</name>
<name sortKey="Zayed, Abdalnasser" sort="Zayed, Abdalnasser" uniqKey="Zayed A" first="Abdalnasser" last="Zayed">Abdalnasser Zayed</name>
<name sortKey="Zeng, Thomas" sort="Zeng, Thomas" uniqKey="Zeng T" first="Thomas" last="Zeng">Thomas Zeng</name>
<name sortKey="Zhao, Chengquan" sort="Zhao, Chengquan" uniqKey="Zhao C" first="Chengquan" last="Zhao">Chengquan Zhao</name>
<name sortKey="Zhao, Yongjun" sort="Zhao, Yongjun" uniqKey="Zhao Y" first="Yongjun" last="Zhao">Yongjun Zhao</name>
</noCountry>
<country name="Canada"><noRegion><name sortKey="Shah, Sohrab P" sort="Shah, Sohrab P" uniqKey="Shah S" first="Sohrab P" last="Shah">Sohrab P. Shah</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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